The demands of modern computing applications have effectively challenged the era of classical approaches. Modern large-scale computing environments are increasingly becoming modular, integrating a wide range of specialisations such as hybrid quantum systems, cloud platforms, ASICs, GPUs, edge IoT devices, and storage, enabling the execution of complex tasks. The slowdown of Moore’s Law, coupled with the growing demands of AI-driven design, necessitates specialised solutions for improved outcomes. Although the landscape remains fragmented, tools that facilitate orchestration across heterogeneous environments are becoming more widespread and valuable in mainstream scientific computing. We envision a lot of innovation in the software layers of the digital infrastructure stack for the coming decades.